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If you are hypersensitive to thyroid hormone. Synthroid has profound effects on the body. An empty stomach, one-half to one hour before breakfast. You are taking Synthroid to make up for a lack of natural hormone, it is important to take it regularly at the same time every day. An appetite-suppressant medication. Synthroid may cause seizures at the beginning of treatment, although this is rare. A naturally occurring hormone produced by the thyroid glands. Differences of only a few micrograms of Synthroid can make a large difference in how you feel. An empty stomach, one-half to one hour before breakfast.